Identification of diverse astrocyte populations and their malignant analogs.

ABSTRACT: Astrocytes are the most abundant cell type in the brain, where they perform a wide array of functions, yet the nature of their cellular heterogeneity and how it oversees these diverse roles remains shrouded in mystery. Using an intersectional fluorescence-activated cell sorting-based strategy, we identified five distinct astrocyte subpopulations present across three brain regions that show extensive molecular diversity. Application of this molecular insight toward function revealed that these populations differentially support synaptogenesis between neurons. We identified correlative populations in mouse and human glioma and found that the emergence of specific subpopulations during tumor progression corresponded with the onset of seizures and tumor invasion. In sum, we have identified sub

SUBMITTER: John Lin CC 

PROVIDER: S-EPMC5824716 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature