A population-based survey of risk for cancer in individuals diagnosed with myotonic dystrophy.

ABSTRACT:

Introduction

The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population.

Methods

Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Cancer Registry. Relative risks were estimated for 36 cancers of different types in 281 DM patients.

Results

Testicular cancer (relative risk [RR] = 10.74; 95% confidence interval [CI], 1.91-38.79), endometrial cancer (RR = 6.98; 95% CI, 1.24-25.22), and non-Hodgkin lymphoma (RR = 4.25; 95% CI, 1.16-12.43) were all observed at significant excess in DM patients.

Conclusions

This study confirms an overall increased risk of cancer in DM. Individuals diagn

SUBMITTER: Abbott D 

PROVIDER: S-EPMC5824717 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature