Ontology highlight
ABSTRACT:
SUBMITTER: Li CW
PROVIDER: S-EPMC5824730 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20180201 2
Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 e ...[more]