Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is a major cause of mortality in critically ill patients. Patients are currently managed by protective ventilation and alveolar recruitment using positive-end expiratory pressure (PEEP). However, the PEEP's effect on both pulmonary metabolism and regional inflammation is poorly understood. Here, we demonstrate the effect of PEEP on pulmonary anaerobic metabolism in mechanically ventilated injured rats, using hyperpolarized carbon-13 imaging. Pulmonary lactate-to-pyruvate ratio was measured in 21 rats; 14 rats received intratracheal instillation of hydrochloric-acid, while 7 rats received sham saline. 1 hour after acid/saline instillation, PEEP was lowered to 0 cmH₂O in 7 injured rats (ZEEP group) and in all sham rats; PEEP was continued

SUBMITTER: Pourfathi M 

PROVIDER: S-EPMC5824838 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature