STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.

ABSTRACT: A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1^hi, but compared to their CD57- PD-1^hi counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly, circulating PD-1+ CD57+ CD4+ T cells make less cytokine than their CD57- PD-1+ counterparts, but have a prominent cytotoxic phenotype. By analysis of responses to STAT3-dependent cytokines and cells from patients with gain- or loss-of-function STAT3 mutations, we show that CD4+ T cell cytotoxicity is STAT3-dependent. TFH formation also requires STAT3, but par

SUBMITTER: Alshekaili J 

PROVIDER: S-EPMC5824848 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature