Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.

ABSTRACT: Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea th

SUBMITTER: Hoffmann T 

PROVIDER: S-EPMC5824889 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature