Diversity and evolution of four-domain voltage-gated cation channels of eukaryotes and their ancestral functional determinants.

ABSTRACT: Four-domain voltage-gated cation channels (FVCCs) represent a large family of pseudo-tetrameric ion channels which includes voltage-gated calcium (Ca_v) and sodium (Na_v) channels, as well as their homologues. These transmembrane proteins are involved in a wide range of physiological processes, such as membrane excitability, rhythmical activity, intracellular signalling, etc. Information about actual diversity and phylogenetic relationships of FVCCs across the eukaryotic tree of life is scarce. We for the first time performed a taxonomically broad phylogenetic analysis of 277 FVCC sequences from a variety of eukaryotes and showed that many groups of eukaryotic organisms have their own clades of FVCCs. Moreover, the number of FVCC lineages in several groups of unicellula

SUBMITTER: Pozdnyakov I 

PROVIDER: S-EPMC5824947 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature