Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.

ABSTRACT:

Background

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.

Objectives

We analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.

Methods

We quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute V

SUBMITTER: Jimenez-Alcazar M 

PROVIDER: S-EPMC5825008 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature