Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink.

ABSTRACT: We examined the association between statin use and the risk of rheumatoid arthritis (RA), with special focus on describing the patterns of risks of RA during statin exposure in a large population-based cohort in the United Kingdom. In the Clinical Practice Research Datalink, patients aged ≥40 years with at least one prescription of statins (1995-2009) were selected, and matched by age (+/-5 years), sex, practice and date of first prescription of statins to non-users. The follow-up period of statin use was divided into periods of current, recent and past exposure, with patients moving between these three exposure categories over time. Time-dependent Cox models were used to derive hazard ratios (HRs) of RA, adjusted for disease history and previous drug use. The study population included 1,0

SUBMITTER: de Jong HJI 

PROVIDER: S-EPMC5825093 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature