Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response.

ABSTRACT:

Objective

We previously identified septic shock endotypes A and B based on 100 genes reflecting adaptive immunity and glucocorticoid receptor signaling. The endotypes differ with respect to outcome and corticosteroid responsiveness. We determined whether endotypes change during the initial 3 days of illness, and whether changes are associated with outcomes.

Design

Observational cohort study including existing and newly enrolled participants.

Setting

Multiple PICUs.

Patients

Children with septic shock.

Interventions

None.

Measurements and main results

We measured the 100 endotyping genes at day 1 and day 3 of illness in 375 patients. We determined if endotype assignment changes over time, and whether changing endotype is associated with corticoster

SUBMITTER: Wong HR 

PROVIDER: S-EPMC5825261 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature