Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development.

ABSTRACT: An increasing body of evidence points to significant spatio-temporal differences in early placental development between mouse and human, but a detailed comparison of placentae in these two species is missing. We set out to compare placentae from both species across gestation, with a focus on trophoblast progenitor markers. We found that CDX2 and ELF5, but not EOMES, are expressed in early post-implantation trophoblast subpopulations in both species. Genome-wide expression profiling of mouse and human placentae revealed clusters of genes with distinct co-expression patterns across gestation. Overall, there was a closer fit between patterns observed in the placentae when the inter-species comparison was restricted to human placentae through gestational week 16 (thus, excluding full-term samp

SUBMITTER: Soncin F 

PROVIDER: S-EPMC5825847 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature