The AMH genotype (rs10407022 T>G) is associated with circulating AMH levels in boys, but not in girls.

ABSTRACT:

Objective

Fetal anti-Müllerian hormone (AMH) is responsible for normal male sexual differentiation, and circulating AMH is used as a marker of testicular tissue in newborns with disorders of sex development. Little is known about the mechanism of action in postnatal life. A recent genome wide association study (GWAS) reported genetic variation of AMH affecting AMH levels in young men. This study investigated the effect of genetic variation of AMH and AMH type II receptor (AMHR2) (AMHrs10407022 T>G and AMHR2rs11170547 C>T) on circulating reproductive hormone levels and pubertal onset in boys and girls.

Design and methods

This study is a combined longitudinal and cross-sectional study in healthy Danish boys and girls from the general population. We included 658 b

SUBMITTER: Greiber IK 

PROVIDER: S-EPMC5825925 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature