Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis.

ABSTRACT: Septation in bacteria requires coordinated regulation of cell wall biosynthesis and hydrolysis enzymes so that new septal cross-wall can be appropriately constructed without compromising the integrity of the existing cell wall. Bacteria with different modes of growth and different types of cell wall require different regulators to mediate cell growth and division processes. Mycobacteria have both a cell wall structure and a mode of growth that are distinct from well-studied model organisms and use several different regulatory mechanisms. Here, using Mycobacterium smegmatis, we identify and characterize homologs of the conserved cell division regulators FtsL and FtsB, and show that they appear to function similarly to their homologs in Escherichia coli We identify a number of

SUBMITTER: Wu KJ 

PROVIDER: S-EPMC5826036 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature