Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo.

ABSTRACT: Although KPC enzymes are most common among carbapenemases produced by Enterobacter cloacae complex globally, the epidemiology varies from one country to another. While previous studies have suggested that IMP enzymes are most common in Japan, detailed analysis has been scarce thus far. Here, we carried out a molecular epidemiological study and plasmid analysis of IMP-1-producing E. cloacae complex isolates collected from three hospitals in central Tokyo using whole-genome sequencing. Seventy-one isolates were classified into several sequence types (STs), and 49 isolates were identified as Enterobacter hormaechei ST78. Isolates of ST78 were divided into three clades by core-genome single nucleotide polymorphism (SNP)-based phylogenetic analysis. Whereas isolates of clad

SUBMITTER: Aoki K 

PROVIDER: S-EPMC5826111 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature