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Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates.

ABSTRACT: Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

SUBMITTER: Top J 

PROVIDER: S-EPMC5826138 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Identification of a Novel Genomic Island Associated with <i>vanD</i>-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates.

Top Janetta J   Sinnige Jan C JC   Brouwer Ellen C EC   Werner Guido G   Corander Jukka J   Severin Juliëtte A JA   Jansen Rogier R   Bathoorn E E   Bonten Marc J M MJM   Rossen John W A JWA   Willems Rob J L RJL  

Antimicrobial agents and chemotherapy 20180223 3

Genomic comparison of the first six Dutch <i>vanD</i>-type vancomycin-resistant <i>Enterococcus faecium</i> (VRE) isolates with four <i>vanD</i> gene clusters from other enterococcal species and anaerobic gut commensals revealed that the <i>vanD</i> gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the <i>vanD</i>-containing genomic island was not species s  ...[more]

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