T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder.

ABSTRACT: While a link between inflammation and the development of neuropsychiatric disorders, including major depressive disorder (MDD) is supported by a growing body of evidence, little is known about the contribution of aberrant adaptive immunity in this context. Here, we conducted in-depth characterization of T cell phenotype and T cell receptor (TCR) repertoire in MDD. For this cross-sectional case-control study, we recruited antidepressant-free patients with MDD without any somatic or psychiatric comorbidities (n = 20), who were individually matched for sex, age, body mass index, and smoking status to a non-depressed control subject (n = 20). T cell phenotype and repertoire were interrogated using a combination of flow cytometry, gene expression analysis, and next generation sequ

SUBMITTER: Patas K 

PROVIDER: S-EPMC5826233 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature