Recovering Genomics Clusters of Secondary Metabolites from Lakes Using Genome-Resolved Metagenomics.

ABSTRACT: Metagenomic approaches became increasingly popular in the past decades due to decreasing costs of DNA sequencing and bioinformatics development. So far, however, the recovery of long genes coding for secondary metabolites still represents a big challenge. Often, the quality of metagenome assemblies is poor, especially in environments with a high microbial diversity where sequence coverage is low and complexity of natural communities high. Recently, new and improved algorithms for binning environmental reads and contigs have been developed to overcome such limitations. Some of these algorithms use a similarity detection approach to classify the obtained reads into taxonomical units and to assemble draft genomes. This approach, however, is quite limited since it can classify exclusively sequ

SUBMITTER: Cuadrat RRC 

PROVIDER: S-EPMC5826242 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature