Intra-species Genomic and Physiological Variability Impact Stress Resistance in Strains of Probiotic Potential.

ABSTRACT: Large-scale microbiome studies have established that most of the diversity contained in the gastrointestinal tract is represented at the strain level; however, exhaustive genomic and physiological characterization of human isolates is still lacking. With increased use of probiotics as interventions for gastrointestinal disorders, genomic and functional characterization of novel microorganisms becomes essential. In this study, we explored the impact of strain-level genomic variability on bacterial physiology of two novel human Lactobacillus rhamnosus strains (AMC143 and AMC010) of probiotic potential in relation to stress resistance. The strains showed differences with known probiotic strains (L. rhamnosus GG, Lc705, and HN001) at the genomic level, including nucleotide polymo

SUBMITTER: Arnold JW 

PROVIDER: S-EPMC5826259 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature