FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.

ABSTRACT: Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for song development. We delineate, for the first time, unique contributions of each isoform to vocal learning. Weighted gene coexpression network analysis of RNA-seq data revealed gene modules correlated to singing, learning, or vocal variability. Coexpression related to singing was found in juvenile and adult Area X whereas coexpression correlated to learning was unique to juveniles. The confluence of le

SUBMITTER: Burkett ZD 

PROVIDER: S-EPMC5826274 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature