Examining the Reticulocyte Preference of Two Plasmodium berghei Strains during Blood-Stage Malaria Infection.

ABSTRACT: The blood-stage of the Plasmodium parasite is one of the key phases within its life cycle that influences disease progression during a malaria infection. The efficiency of the parasite in infecting red blood cells (RBC) determines parasite load and parasite-induced hemolysis that is responsible for the development of anemia and potentially drives severe disease progression. However, the molecular factors defining the infectivity of Plasmodium parasites have not been completely identified so far. Using the Plasmodium berghei mouse model for malaria, we characterized and compared the blood-stage infection dynamics of PbANKA WT and a mutant parasite strain lacking a novel Plasmodium antigen, PbmaLS_05, that is well conserved in both human and animal <

SUBMITTER: Thakre N 

PROVIDER: S-EPMC5826286 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature