Novel Variant of New Delhi Metallo-β-lactamase, NDM-20, in Escherichia coli.

ABSTRACT: The spread of carbapenem-resistant Enterobacteriaceae (CRE) mediated by New Delhi metallo-β-lactamase (NDM) poses a serious challenge to clinicians and has become a major public health concern. NDM has been evolving into variants that possess different hydrolysis activity toward antibiotics, so as to affect treatment strategy. In addition, very few studies on NDM variants have focused on animal-derived bacterial isolates. Our study reports a novel NDM variant, NDM-20, in an isolate of Escherichia coli CCD1 recovered from the food animal swine in China. The isolate that was assigned to ST1114, exhibited high level resistance to all β-lactams tested, including aztreonam and carbapenems. The gene of bla_NDM-20 was located on an IncX3-type plasmid, surrounded by multipl

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5826333 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature