The Small RNA RyhB Is a Regulator of Cytochrome Expression in Shewanella oneidensis.

ABSTRACT: Shewanella oneidensis produces an extensive electron transfer network that results in metabolic flexibility. A large number of c-type cytochromes are expressed by S. oneidensis and these function as the fundamental electron transport chain proteins. Although several S. oneidensis cytochromes have been well-characterized, little is known about how their expression is regulated. In this study, we investigate the role of the ferric uptake regulator (Fur) and the sRNA RyhB in regulation. Our results demonstrate that loss of Fur leads to diminished growth and an apparent decrease in heme-containing proteins. Remarkably, deleting the Fur-repressed ryhB gene almost completely reverses these physiological changes, indicating that the phenotypes resulting from los

SUBMITTER: Meibom KL 

PROVIDER: S-EPMC5826389 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature