Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.

ABSTRACT: The conserved function of protein phosphorylation, catalysed by members of protein kinase superfamily, is regulated in different ways in different kinase families. Further, differences in activating triggers, cellular localisation, domain architecture and substrate specificity between kinase families are also well known. While the transfer of γ-phosphate from ATP to the hydroxyl group of Ser/Thr/Tyr is mediated by a conserved Asp, the characteristic functional and regulatory sites are specialized at the level of families or sub-families. Such family-specific sites of functional specialization are unknown for most families of kinases. In this work, we systematically identify the family-specific residue features by comparing the extent of conservation of physicochemical properties, Shannon e

SUBMITTER: Kalaivani R 

PROVIDER: S-EPMC5826538 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature