A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields.

ABSTRACT: The spike trains of retinal ganglion cells (RGCs) are the only source of visual information to the brain. Here, we genetically identify an RGC type in mice that functions as a pixel encoder and increases firing to light increments (Pix_ON-RGC). Pix_ON-RGCs have medium-sized dendritic arbors and non-canonical center-surround receptive fields. From their receptive field center, Pix_ON-RGCs receive only excitatory input, which encodes contrast and spatial information linearly. From their receptive field surround, Pix_ON-RGCs receive only inhibitory input, which is temporally matched to the excitatory center input. As a result, the firing rate of Pix_ON-RGCs linearly encodes local image contrast. Spatially offset (i.e., truly lateral) inhibitio

SUBMITTER: Johnson KP 

PROVIDER: S-EPMC5826572 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature