Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

ABSTRACT: There is a growing interest in the use of lipid bilayer nanodiscs for various biochemical and biomedical applications. Among the different types of nanodiscs, the unique features of synthetic polymer-based nanodiscs have attracted additional interest. A styrene-maleic acid (SMA) copolymer demonstrated to form lipid nanodiscs has been used for structural biology related studies on membrane proteins. However, the application of SMA polymer based lipid nanodiscs is limited because of the strong absorption of the aromatic group interfering with various experimental measurements. Thus, there is considerable interest in the development of other molecular frameworks for the formation of polymer-based lipid nanodiscs. In this study, we report the first synthesis and characterization of a library o

SUBMITTER: Yasuhara K 

PROVIDER: S-EPMC5826593 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature