Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice.

ABSTRACT: Spaceflight has been shown to suppress the adaptive immune response, altering the distribution and function of lymphocyte populations. B lymphocytes express highly specific and highly diversified receptors, known as immunoglobulins (Ig), that directly bind and neutralize pathogens. Ig diversity is achieved through the enzymatic splicing of gene segments within the genomic DNA of each B cell in a host. The collection of Ig specificities within a host, or Ig repertoire, has been increasingly characterized in both basic research and clinical settings using high-throughput sequencing technology (HTS). We utilized HTS to test the hypothesis that spaceflight affects the B-cell repertoire. To test this hypothesis, we characterized the impact of spaceflight on the unimmunized Ig repertoire of C57B

SUBMITTER: Ward C 

PROVIDER: S-EPMC5826609 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature