Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.

ABSTRACT:

Background

Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.

Methods

This study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis acro

SUBMITTER: Walton E 

PROVIDER: S-EPMC5826665 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature