Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy.

ABSTRACT:

Background

Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and geographically clusters in poor communities. The Area Deprivation Index (ADI) is a neighborhood-level index derived from census data that reflects material disadvantage.

Methods

We performed a geospatial analysis to determine if ADI predicts the local odds of CMV seropositivity. We analyzed a dataset of 3527 women who had been tested for CMV antibodies during pregnancy. We used generalized additive models to analyze the spatial distribution of CMV seropositivity. Adjusted models included individual-level age and race and neighborhood-level ADI.

Results

Our dataset included 1955 CMV seroposit

SUBMITTER: Lantos PM 

PROVIDER: S-EPMC5826762 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature