Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study.

ABSTRACT: Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p < 5.0 × 10^-8) for the NOX4 locus (lead variant rs2289125, β = -0.15, p = 5.3 × 10¹¹). While the NOX4 locus was previously reported as associated with Hcy in European-American populations, rs2289125 remained

SUBMITTER: Raffield LM 

PROVIDER: S-EPMC5826839 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature