Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.

ABSTRACT:

Background

Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy.

Objective

To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.

Method

Gait function was evaluated on two days for patients (ON and OFF medication in a counterbalanced fashion) and a single session for controls. Investigators were blinded to genotype during data collection. Associations between genotype and medication responsivene

SUBMITTER: Miller NS 

PROVIDER: S-EPMC5826846 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature