Ultrasound-Mediated Microbubble Destruction Suppresses Melanoma Tumor Growth.

ABSTRACT: Melanoma is one of the most aggressive types of cancer, and its incidence has increased rapidly in the past few decades. In this study, we investigated a novel treatment approach, the use of low-intensity ultrasound (2.3 W/cm² at 1 MHz)-mediated Optison microbubble (MB) destruction (UMMD) to treat melanoma in a flank tumor model. The effect of UMMD was first evaluated in the melanoma cell line B16 F10 (B16) in vitro and then in mice inoculated with B16 cells. MB⁺B16 cells were exposed to US in vitro, resulting in significant cell death proportional to duty cycle (R² = 0.74): approximately 30%, 50%, 80% and 80% cell death at 10%, 30%, 50% and 100% DC respectively. Direct implantation of tumors with MBs, followed by sonication, resulted in retarded tumor grow

SUBMITTER: Jang KW 

PROVIDER: S-EPMC5826859 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature