Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish.

ABSTRACT: Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, b

SUBMITTER: Suniaga S 

PROVIDER: S-EPMC5826918 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature