HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection.

ABSTRACT: Macrophages are important innate immune defense system cells in the fight against bacterial and fungal pathogenic infections. They exhibit significant plasticity, particularly with their ability to undergo functional differentiation. Additionally, HIF1α is critically involved in the functional differentiation of macrophages during inflammation. However, the role of macrophage HIF1α in protecting against different pathogenic infections remains unclear. In this study, we investigated and compared the roles of HIF1α in different macrophage functional effects of bacterial and fungal infections in vitro and in vivo. We found that bacterial and fungal infections produced similar effects on macrophage functional differentiation. HIF1α deficiency inhibited pro-inflammatory macrophage functional ac

SUBMITTER: Li C 

PROVIDER: S-EPMC5827022 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature