Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner.

ABSTRACT: Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4⁺ splenic T cells, and significantly higher CD69 expression on CD8⁺ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after recei

SUBMITTER: Bolognese AC 

PROVIDER: S-EPMC5827170 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature