Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir.

ABSTRACT: It is discovered that sustained cytosolic drug release at a sufficient concentration is an effective mechanism to circumvent multidrug resistance and consequently enhance antitumor drug efficacy. It is showed that a simple way to enable this mechanism is to reach an intracellular kinetic balance of the drug movement between the drug released from the carrier into the cytosol and the one removed from the cell interior. By adopting nanoparticle (NP) as the drug carrier, a reservoir of drug can be maintained inside the cells upon effective cellular uptake of these NPs via endocytosis. This study shows that gradual release of the drug from the NP carrier provides a feasible scheme for sustained drug release in cells, resulting in relatively stable cytosolic drug concentration level, particular

SUBMITTER: Fan L 

PROVIDER: S-EPMC5827467 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature