Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?

ABSTRACT: Over the past century, solid organ transplantation has been improved both at a surgical and postoperative level. However, despite the improvement in efficiency, safety, and survival, we are still far from obtaining full acceptance of all kinds of allograft in the absence of concomitant treatments. Today, transplanted patients are treated with immunosuppressive drugs (IS) to minimize immunological response in order to prevent graft rejection. Nevertheless, the lack of specificity of IS leads to an increase in the risk of cancer and infections. At this point, cell therapies have been shown as a novel promising resource to minimize the use of IS in transplantation. The main strength of cell therapy is the opportunity to generate allograft-specific tolerance, promoting in this way long-term al

SUBMITTER: Marin E 

PROVIDER: S-EPMC5827529 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature