GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

ABSTRACT: Collecting ducts make up the distal-most tubular segments of the kidney, extending from the cortex, where they connect to the nephron proper, into the medulla, where they release urine into the renal pelvis. During water deprivation, body water preservation is ensured by the selective transepithelial reabsorption of water into the hypertonic medullary interstitium mediated by collecting ducts. The collecting duct epithelium forms tight junctions composed of barrier-enforcing claudins and exhibits a higher transepithelial resistance than other segments of the renal tubule exhibit. However, the functional relevance of this strong collecting duct epithelial barrier is unresolved. Here, we report that collecting duct-specific deletion of an epithelial transcription factor, grainyhead-like 2 (G

SUBMITTER: Hinze C 

PROVIDER: S-EPMC5827589 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature