Fibrotic Venous Remodeling and Nonmaturation of Arteriovenous Fistulas.

ABSTRACT: The frequency of primary failure in arteriovenous fistulas (AVFs) remains unacceptably high. This lack of improvement is due in part to a poor understanding of the pathobiology underlying AVF nonmaturation. This observational study quantified the progression of three vascular features, medial fibrosis, intimal hyperplasia (IH), and collagen fiber organization, during early AVF remodeling and evaluated the associations thereof with AVF nonmaturation. We obtained venous samples from patients undergoing two-stage upper-arm AVF surgeries at a single center, including intraoperative veins at the first-stage access creation surgery and AVFs at the second-stage transposition procedure. Paired venous samples from both stages were used to evaluate change in these vascular features after anastomosis

SUBMITTER: Martinez L 

PROVIDER: S-EPMC5827597 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature