Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.

ABSTRACT: Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to disease. Human kidney development initiates around 4 weeks of gestation and ends around 34-37 weeks of gestation. Over this period, a reiterative inductive process establishes the nephron complement. Studies have provided insightful anatomic descriptions of human kidney development, but the limited histologic views are not readily accessible to a broad audience. In this first paper in a series providing comprehensive insight into human kidney formation, we examined human kidney development in 135 anonymously donated human kidney specimens. We documented kidney development at a macroscopic and cellular level through histologic analysis, RNA

SUBMITTER: Lindstrom NO 

PROVIDER: S-EPMC5827606 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature