Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.

ABSTRACT: The nephron is the functional unit of the kidney, but the mechanism of nephron formation during human development is unclear. We conducted a detailed analysis of nephron development in humans and mice by immunolabeling, and we compared human and mouse nephron patterning to describe conserved and divergent features. We created protein localization maps that highlight the emerging patterns along the proximal-distal axis of the developing nephron and benchmark expectations for localization of functionally important transcription factors, which revealed unanticipated cellular diversity. Moreover, we identified a novel nephron subdomain marked by Wnt4 expression that we fate-mapped to the proximal mature nephron. Significant conservation was observed between human and mouse patterning. W

SUBMITTER: Lindstrom NO 

PROVIDER: S-EPMC5827611 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature