Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.

ABSTRACT: Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use. In the current study, a morphine-murine model was used to investigate the role of the gut microbiome and metabolome as a potential mechanism contributing to the negative consequences associated with opioid use. Results reveal a significant shift in the gut microbiome and metabolome within one day following morphine treatment compared to that observed after placebo. Morphine-induced gut microbial dysbiosis exhibited distinct characteristic signatures, including significant increase in communities associated with pathogenic function, decrease in communities associated with str

SUBMITTER: Wang F 

PROVIDER: S-EPMC5827657 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature