Peptide conjugated magnetic nanoparticles for magnetically mediated energy delivery to lung cancer cells.

ABSTRACT:

Aim

In the present study, we examine the effects of internalized peptide-conjugated iron oxide nanoparticles and their ability to locally convert alternating magnetic field (AMF) energy into other forms of energy (e.g., heat and rotational work).

Materials & methods

Dextran-coated iron oxide nanoparticles were functionalized with a cell penetrating peptide and after internalization by A549 and H358 cells were activated by an AMF.

Results

TAT-functionalized nanoparticles and AMF exposure increased reactive oxygen species generation compared with the nanoparticle system alone. The TAT-functionalized nanoparticles induced lysosomal membrane permeability and mitochondrial membrane depolarization, but these effects were not further enhanced by AMF treatment. Although not s

SUBMITTER: Hauser AK 

PROVIDER: S-EPMC5827791 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature