A systematic literature review of the efficacy, effectiveness, and safety of filgrastim.

ABSTRACT:

Purpose

Filgrastim (NEUPOGEN^®) is the originator recombinant human granulocyte colony-stimulating factor widely used for preventing neutropenia-related infections and mobilizing hematopoietic stem cells. This report presents findings of a systematic literature review and meta-analysis of efficacy and safety of originator filgrastim to update previous reports.

Methods

A literature search of electronic databases, congress abstracts, and bibliographies of recent reviews was conducted to identify English-language reports of clinical trials and observational studies evaluating filgrastim in its US-approved indications up to February 2015. Two independent reviewers assessed titles/abstracts and full texts of publications, and extracted data from studies that compared or

SUBMITTER: Dale DC 

PROVIDER: S-EPMC5827957 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature