Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy.

ABSTRACT:

Background

Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic therapy (PDT) has gained a major attention owing to the limitless penetration of X-rays. However, substantial outcomes have still not been achieved due to the low luminescence efficiency of scintillating nanoparticles and weak energy transfer to the photosensitizer. The present work describes the development of Y_2.99Pr_0.01Al₅O₁₂-based (YP) mesoporous silica coated nanoparticles, multifunctionalized with protoporphyrin IX (PpIX) and folic acid (YPMS@PpIX@FA) for potential application in targeted deep PDT.

Results

A YP nanophosphor

SUBMITTER: Sengar P 

PROVIDER: S-EPMC5827996 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature