Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study.

ABSTRACT:

Background

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies. On July 10, 1976, a chemical explosion in Seveso, Italy, exposed nearby residents to a high amount of TCDD. In 1996, the Seveso Women's Health Study (SWHS) was established to study the effects of TCDD on women's health. Using data from the Seveso Second Generation Health Study, we aim to examine the effect of prenatal exposure to TCDD on the risk of atopic conditions in SWHS children born after the explosion.

Methods

Individual-level TCDD was measured in maternal serum collected soon after the accident. In 2014, we initiated the Seves

SUBMITTER: Ye M 

PROVIDER: S-EPMC5827999 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature