Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels.

ABSTRACT:

Background

There are two main types of lung cancer: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC has many subtypes, but the two most common are lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). These subtypes are mainly classified by physiological and pathological characteristics, although there is increasing evidence of genetic and molecular differences as well. Although some work has been done at the somatic level to explore the genetic and biological differences among subtypes, little work has been done that interrogates these differences at the germline level to characterize the unique and shared susceptibility genes for each subtype.

Methods

We used single-nucleotide polymorphisms (SNPs) from a genome-wide association stu

SUBMITTER: O'Brien TD 

PROVIDER: S-EPMC5828003 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature