Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.

ABSTRACT:

Background

Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer's disease (AD) pathology. A clinical cerebrospinal fluid biomarker capable of monitoring this process during the course of the disease has yet to emerge, chiefly owing to contradictory research findings. In this study, we sought to clarify the utility of inflammatory biomarkers in diagnostic procedures of AD in three steps: (1) to screen for proteins that are robustly detectable in cerebrospinal fluid; (2) based on this analysis, to explore any associations between the analytically robust markers and salient pathological features of AD; and (3) to determine the discriminative power of these markers in the clinical diagnosis of AD.

Methods

From a total of 46 proteins,

SUBMITTER: Brosseron F 

PROVIDER: S-EPMC5828084 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature