Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes.

ABSTRACT:

Background

The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this varying breadth of the autoantibody profile is associated with treatment outcomes. Therefore, we investigated whether the composition of the autoantibody profile in RA, as a marker of the underlying immunopathology, influences initial and long-term treatment outcomes.

Methods

In serum from 399 seropositive patients with RA in the IMPROVED study, drawn at baseline and at the moment of drug tapering, we measured IgG, IgM, and IgA isotypes for anti-cyclic citrullinated peptide-2 and anti-carbamylated protein antibodies, IgM and IgA rheumatoid factor, and reactivi

SUBMITTER: de Moel EC 

PROVIDER: S-EPMC5828136 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature