Self-administration of intranasal influenza vaccine: Immunogenicity and volunteer acceptance.

ABSTRACT:

Background

In outbreak settings, mass vaccination strategies could maximize health protection of military personnel. Self-administration of live attenuated influenza vaccine (LAIV) may be a means to vaccinate large numbers of people and achieve deployment readiness while sparing the use of human resources.

Methods

A phase IV, open-label, randomized controlled trial evaluating the immunogenicity and acceptance of self-administered (SA) LAIV was conducted from 2012 to 2014. SA subjects were randomized to either individual self-administration or self-administration in a group setting. Control randomized subjects received healthcare worker-administered (HCWA) LAIV. Anti-hemagglutinin (HAI) antibody concentrations were measured pre- and post-vaccination. The primary endpoint was

SUBMITTER: Burgess TH 

PROVIDER: S-EPMC5828152 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature