Effective impairment of myeloma cells and their progenitors by hyperthermia.
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ABSTRACT:
SUBMITTER: Miki H
PROVIDER: S-EPMC5828190 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Effective impairment of myeloma cells and their progenitors by hyperthermia.
Miki Hirokazu H Nakamura Shingen S Oda Asuka A Tenshin Hirofumi H Teramachi Jumpei J Hiasa Masahiro M Bat-Erdene Ariunzaya A Maeda Yusaku Y Oura Masahiro M Takahashi Mamiko M Iwasa Masami M Harada Takeshi T Fujii Shiro S Kurahashi Kiyoe K Yoshida Sumiko S Kagawa Kumiko K Endo Itsuro I Aihara Kenichi K Ikuo Mariko M Itoh Kohji K Hayashi Koichiro K Nakamura Michihiro M Abe Masahiro M
Oncotarget 20171207 12
Multiple myeloma (MM) remains incurable, and MM-initiating cells or MM progenitors are considered to contribute to disease relapse through their drug-resistant nature. In order to improve the therapeutic efficacy for MM, we recently developed novel superparamagnetic nanoparticles which selectively accumulate in MM tumors and extirpate them by heat generated with magnetic resonance. We here aimed to clarify the therapeutic effects on MM cells and their progenitors by hyperthermia. Heat treatment ...[more]
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